Product Overview
Generic name: compound glycyrrhizin capsules
Chinese Pinyin: FuFangGanCaoSuanGanJiaoNang
Product name: Kain Gan Le
Ingredients: This product is a compound preparation. Each capsule contains 25mg of glycyrrhizin, 25mg of glycine, and 25mg of methionine. As excipients, it also contains lactose, calcium carbonate, microcrystalline cellulose, sodium carboxymethyl starch, talcum powder, and stearic acid. Appropriate amount of magnesium and povidone k30.
Properties: This product is a capsule, the content is light yellow granules.
Indications: Treat chronic liver disease and improve liver function abnormalities. It can be used to treat eczema, dermatitis, and alopecia areata.
Specification: 25mg*40 capsules/box
Usage and Dosage: Adults usually take 2-3 capsules at a time, and children take 1 capsule at a time, 3 times a day, orally after meals. The symptoms may increase or decrease according to age.
Adverse reactions: Hypokalemia, elevated blood pressure, blood sodium and body fluid retention, edema, weight gain and other pseudo-aldosteronism can be seen after large or long-term administration of glycyrrhizic acid. For its pathogenesis, Kumagai believes that glycyrrhizic acid and its metabolite glycyrrhetinic acid inhibit the activity of the metabolic enzyme Δ4-reductase (Δ4-reductase) of Δ4- 3Ketocteroid (sterones) in the liver; Stewort believes that, It is because glycyrrhetinic acid in the kidney inhibits the activity of the metabolic enzyme 11β-HCD (11-β-hydroxysteroid dehydrogenase) that converts cortisol into cortisone, so that excess hydrocortisone replaces aldosterone and kidney type I receptors. The body binds, thus playing a hydrocorticoid-like effect. When healthy people are given glycyrrhizic acid for a long time, different levels of hydrocorticosteroid-like effects can also be seen. In addition, there are also reports that glycyrrhizic acid inhibits 11β-HCD activity and leads to abnormal steroid metabolism [9]. However, the emergence of pseudoaldosteronism is also limited to patients who have given glycyrrhizic acid or glycyrrhizic acid in large amounts or for a long time, and these patients are also related to individual differences [10]. In fact, patients with chronic hepatitis were treated with SNMC in a double-blind way, and 80 mg of glycyrrhizic acid was injected intravenously for 4 weeks. No pseudoaldosteronism was seen. This is related to the route of administration and the size of the dose, as well as to the compound preparation. The potential pseudo-aldosterone effect of glycyrrhizic acid can be weakened by the glycine and L-cysteine contained in the compound preparation. The daily high-dose SNMC100ml therapy also rarely causes adverse reactions. Hino reported that among 65 patients, 1 case of hypertension (1.5%) and 5 cases of hypokalemia (7.5%) were found, but they were all mild, with blood potassium levels above 3.0mEg/L. No serious adverse reactions requiring drug discontinuation were seen. Therefore, when applying compound glycyrrhizin injection and compound glycyrrhizin tablets, it is necessary to regularly check electrolytes (especially the serum potassium level) and measure blood pressure. When serum potassium decreases, consider stopping the drug. In the case of obvious hypokalemia, potassium therapy is often given, but it is found that the amount of potassium excretion in the urine has also increased. The increase in blood potassium also corrected the increase in blood pressure.
Contraindications: The following patients should not be administered:
1. Patients with aldosteronism, myopathy, and hypokalemia (can aggravate hypokalemia and hypertension).
2. Patients with end-stage liver cirrhosis who have a tendency to increase blood ammonia (the metabolite of methionine contained in the preparation can inhibit urea synthesis and reduce the ability to handle ammonia).
Precautions :
1. Cautious administration: Caution should be given to elderly patients (the incidence of hypokalemia in elderly patients is high) (refer to medication for the elderly).
2. General precautions Since this preparation contains glycyrrhizin, it can increase the content of glycyrrhizin in the body when it is used in combination with other licorice preparations, which is prone to pseudo-aldosteronism, so attention should be paid.
Drug interactions: 1. Attention should be paid when combined medication: Combined with loop diuretics, diuretic acid, furosemide, etc., thiazides and antihypertensive diuretics, triclosan, chlorthalidone, etc., hypoemia may occur Potassium (fatigue, low muscle strength) requires full attention to observe the serum potassium level.
2. Mechanism and consequences: Diuretics can enhance the potassium excretion effect of glycyrrhizic acid contained in the preparation, and further lower serum potassium.
Pharmacology and Toxicology: 1. Anti-inflammatory effect: (1) Anti-allergic effect: Glycyrrhizin has anti-allergic effects such as inhibiting rabbit local allergic reactions (Arthus Phenomenon) and inhibiting Schwartzman Phenomenon. For corticosteroids, it can enhance the hormone's anti-stress response and antagonize the hormone's anti-granulation and thymic atrophy. No effect on the exudation of hormones. (2) Inhibition of arachidonic acid metabolism enzymes. Glycyrrhizin can directly bind to phospholipase A2 (phospholipase A2), the initiating enzyme of the arachidonic acid metabolic pathway, and can act on arachidonic acid to cause inflammation. The mediator's lipoxygenase (lipoxygenase) binds to selectively hinder the phosphorylation of these enzymes and inhibit their activation.
2. Immunomodulatory effects: Glycyrrhizin has the following immunomodulatory effects in in vitro tests: (1) Regulating T cell activation; (2) Inducing interferon gamma; (3) Activating NK cells Function; (4) Promote the differentiation of extrathymic T lymphocytes.
3. Inhibition of experimental liver cell injury In the primary cultured rat liver cell line in vitro, glycyrrhizin can inhibit the liver cell injury caused by carbon tetrachloride.
4. Inhibit the proliferation of the virus and inactivate the virus. In the mouse MHV (mouse hepatitis virus) infection experiment, the administration of glycyrrhizin can prolong its survival; in the rabbit vaccinia virus (Vaccinia virus) acne prevention experiment Among them, it has the effect of preventing acne; in the in vitro experiment system, the effect of inhibiting the proliferation of herpes virus and the inactivation of the virus has also been observed. It has been reported that glycine and methionine can inhibit the decrease in urine output and sodium excretion caused by oral administration of glycyrrhizin to rats.
Pharmacokinetics: Unclear
Medications for pregnant women and breastfeeding women: Pregnant women and breastfeeding women should use drugs with caution after weighing the advantages of treatment over the disadvantages.
Medication for children: Take 1 capsule once a time for children, 3 times a day, orally after meals.
Medication for elderly patients: With clinical experience, the elderly are prone to adverse reactions to hypokalemia. Therefore, they must be administered carefully on the basis of close observation.
Overdose: Unclear
Storage: sealed and stored at room temperature.
Packaging: Aluminum-plastic blister packaging, 10 tablets/board, 4 boards/box.
Validity period: 24 months
Approval number: National Medicine Standard H20080006
Company Name: Beijing Kaiin Technology Co., Ltd.
